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Parneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 w ithout evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging an d at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone. |
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anosmia
anti Hu antibody
autoantibodies
basal ganglia
basal ganglia,lesion of
basal ganglia,lesion,bilateral
carcinoma
carcinoma of lung
chemotherapy,CNS treatment and complications with
chorea
chorea,causes of
collapsin response mediator protein 5 IgG
encephalitis
hemichorea
limbic encephalitis
lymphoma
lymphoma involving CNS
movement disorder
MRI
MRI,abnormal
MRI,disappearing lesion on
remote effect of cancer on the nervous system
renal cell carcinoma
smell
steroid therapy,CNS treatment and complications with
striatal encephalitis
striatum,lesion of
striatum,lesion of,bilateral
treatment of neurologic disorder
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